Animal models of substance abuse and addiction: implications for science, animal welfare, and society.
Animal models of substance abuse and addiction: implications for science, animal welfare, and society.
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发表时间：
2010-06
影响因子：
0.8
通讯作者：
W. J. Lynch;K. Nicholson;M. Dance;R. W. Morgan;P. Foley
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文献类型：
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作者：
W. J. Lynch;K. Nicholson;M. Dance;R. W. Morgan;P. Foley
药物滥用和成瘾是公认的公共卫生问题，国家卫生研究院的两个研究所（国家药物滥用研究所和国家酒精滥用和酒精中毒研究所）专门针对这一社会问题。因此，这是一个重要的研究领域，动物实验在其中发挥着关键作用。本概述介绍了物质滥用和成瘾在社会中的重要性;回顾了动物模型的发展和完善，这些模型涉及生物学，病理生理学，临床治疗和药物滥用责任筛查的关键领域;并讨论了与这些模型相关的一些独特的兽医，畜牧业和IACUC挑战。
Substance abuse and addiction are well recognized public health concerns, with 2 NIH institutes (the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism) specifically targeting this societal problem. As such, this is an important area of research for which animal experiments play a critical role. This overview presents the importance of substance abuse and addiction in society; reviews the development and refinement of animal models that address crucial areas of biology, pathophysiology, clinical treatments, and drug screening for abuse liability; and discusses some of the unique veterinary, husbandry, and IACUC challenges associated with these models.