Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort
Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort
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DOI：
10.1136/annrheumdis-2011-200975
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发表时间：
2012-07-01
影响因子：
27.4
通讯作者：
Mariette, Xavier
中科院分区：
文献类型：
--
作者：
Gottenberg, Jacques-Eric;Dayer, Jean-Michel;Mariette, Xavier
目的确定早期类风湿关节炎（RA）患者血清细胞因子的特定模式，该模式与类风湿关节炎（RA）的诊断、活动性和严重程度以及B细胞活化的血清标志物水平相关。方法血清白细胞介素（IL）-1 β、IL-1受体拮抗剂（IL 1-Ra）、IL-2、IL-4、IL-6、IL-10、IL-17、IL-21、IL-17单核细胞趋化蛋白1（MCP-1）、肿瘤坏死因子α和干扰素γ的水平在（ESPOIR）最近的早期关节炎队列中测量，该队列包括至少两个关节肿胀>6周的患者，
Objective To identify a specific pattern of serum cytokines that correlates with the diagnosis, activity and severity of rheumatoid arthritis (RA) in patients with early RA as well as with the level of serum markers of B cell activation.Methods Serum interleukin (IL)-1 beta, IL-1 receptor antagonist (IL1-Ra), IL-2, IL-4, IL-6, IL-10, IL-17, IL-21, monocyte chemotactic protein 1 (MCP-1), tumour necrosis factor alpha and interferon gamma levels were measured in the (ESPOIR) Etude et Suivi des POlyarthrites Indifferenciees Recentes early arthritis cohort, which included patients with at least two swollen joints for >6 weeks and