Endosomal targeting by the cytoplasmic tail of membrane immunoglobulin.
Endosomal targeting by the cytoplasmic tail of membrane immunoglobulin.
复制标题
膜免疫球蛋白胞质尾部的内体靶向。
DOI：
10.1126/science.276.5311.407
复制
发表时间：
1997
期刊：
影响因子：
56.9
通讯作者：
M. Reth
中科院分区：
文献类型：
--
作者：
P. Weiser;R. Müller;U. Braun;M. Reth
Membrane-bound immunoglobulin (mIg) of the IgG, IgA, and IgE classes have conserved cytoplasmic tails. To investigate the function of these tails, a B cell line was transfected with truncated or mutated gamma2a heavy chains. Transport to the endosomal compartment of antigen bound by the B cell antigen receptor did not occur in the absence of the cytoplasmic tail; and one or two mutations, respectively, in the Tyr-X-X-Met motif of the tail partially or completely interrupted the process. Experiments with chimeric antigen receptors confirmed these findings. Thus, a role for the cytoplasmic tail of mIg heavy chains in endosomal targeting of antigen is revealed.
mu 跨膜突变会破坏内质网保留。
DOI：
--
发表时间：
1994
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Stevens,TL;Blum,JH;Foy,SP;Matsuuchi,L;DeFranco,AL
通讯作者：
DeFranco,AL