Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.
Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.
复制标题
DOI：
10.3233/jad-220886
复制
发表时间：
2023
影响因子：
4
通讯作者：
Merrill, David A.
中科院分区：
文献类型：
--
作者：
Meysami, Somayeh;Raji, Cyrus A.;Glatt, Ryan M.;Popa, Emily S.;Ganapathi, Aarthi S.;Bookheimer, Tess;Slyapich, Colby B.;Pierce, Kyron P.;Richards, Casey J.;Lampa, Melanie G.;Gill, Jaya M.;Rapozo, Molly K.;Hodes, John F.;Tongson, Ynez M.;Wong, Claudia L.;Kim, Mihae;Porter, Verna R.;Kaiser, Scott A.;Panos, Stella E.;Dye, Richelin, V;Miller, Karen J.;Bookheimer, Susan Y.;Martin, Neil A.;Kesari, Santosh;Kelly, Daniel F.;Bramen, Jennifer E.;Siddarth, Prabha;Merrill, David A.
力量和流动性对于日常生活至关重要。
建模手工束强度，迁移率和MRI容量之间的关系。
我们选择了38名患有阿尔茨海默氏病的参与者：淀粉样蛋白病的生物标志物和手工差的人与手工差异相结合。 oreader调整年龄，性别，教育，授课，体重指数和头部大小的手工束强度，不对称性和2MWT，我们通过分析协方差对非烦恼与脑结构的关系进行了建模。
较高的非义务手柄强度与海马中的较大体积有关（p = 0.02）与较高的额叶体积有关（P = 0.02）。 （p = 0.005）体积脆弱与额叶，临时和顶叶的减少有关。
较大的手夹强度和迁移率与较大的海马和小叶脑体积有关。
Strength and mobility are essential for activities of daily living. With aging, weaker handgrip strength, mobility, and asymmetry predict poorer cognition. We therefore sought to quantify the relationship between handgrip metrics and volumes quantified on brain magnetic resonance imaging (MRI). To model the relationships between handgrip strength, mobility, and MRI volumetry. We selected 38 participants with Alzheimer’s disease dementia: biomarker evidence of amyloidosis and impaired cognition. Handgrip strength on dominant and non-dominant hands was measured with a hand dynamometer. Handgrip asymmetry was calculated. Two-minute walk test (2MWT) mobility evaluation was combined with handgrip strength to identify non-frail versus frail persons. Brain MRI volumes were quantified with Neuroreader. Multiple regression adjusting for age, sex, education, handedness, body mass index, and head size modeled handgrip strength, asymmetry and 2MWT with brain volumes. We modeled non-frail versus frail status relationships with brain structures by analysis of covariance. Higher non-dominant handgrip strength was associated with larger volumes in the hippocampus (p = 0.02). Dominant handgrip strength was related to higher frontal lobe volumes (p = 0.02). Higher 2MWT scores were associated with larger hippocampal (p = 0.04), frontal (p = 0.01), temporal (p = 0.03), parietal (p = 0.009), and occipital lobe (p = 0.005) volumes. Frailty was associated with reduced frontal, temporal, and parietal lobe volumes. Greater handgrip strength and mobility were related to larger hippocampal and lobar brain volumes. Interventions focused on improving handgrip strength and mobility may seek to include quantified brain volumes on MR imaging as endpoints.