MEGA: A biologist-centric software for evolutionary analysis of DNA and protein sequences
MEGA: A biologist-centric software for evolutionary analysis of DNA and protein sequences
复制标题
DOI：
10.1093/bib/bbn017
复制
发表时间：
2008-07-01
影响因子：
9.5
通讯作者：
Tamura, Koichiro
中科院分区：
文献类型：
--
作者：
Kumar, Sudhir;Nei, Masatoshi;Tamura, Koichiro
分子进化遗传学分析（MEGA）软件是一个桌面应用程序，用于比较分析来自多基因家族或不同物种的同源基因序列，特别强调推断DNA和蛋白质进化的进化关系和模式。除了用于数据统计分析的工具之外，MEGA还提供了许多便利的设施，用于从文件或基于网络的存储库组装序列数据集，并且它包括用于以交互式系统发育树和进化距离矩阵的形式可视化呈现所获得的结果的工具。在这里，我们讨论的动机，设计原则和优先事项，塑造了MEGA的发展。我们还讨论了MEGA在未来可能如何发展，以帮助研究人员在他们日益增长的需要，使用新的计算方法来分析大型数据集。
The Molecular Evolutionary Genetics Analysis (MEGA) software is a desktop application designed for comparative analysis of homologous gene sequences either from multigene families or from different species with a special emphasis on inferring evolutionary relationships and patterns of DNA and protein evolution. In addition to the tools for statistical analysis of data, MEGA provides many convenient facilities for the assembly of sequence data sets from files or web-based repositories, and it includes tools for visual presentation of the results obtained in the form of interactive phylogenetic trees and evolutionary distance matrices. Here we discuss the motivation, design principles and priorities that have shaped the development of MEGA. We also discuss how MEGA might evolve in the future to assist researchers in their growing need to analyze large data set using new computational methods.