Present and future therapies of hepatitis B: From discovery to cure.
Present and future therapies of hepatitis B: From discovery to cure.
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DOI：
10.1002/hep.28025
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Lok AS
中科院分区：
文献类型：
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作者：
Liang TJ;Block TM;McMahon BJ;Ghany MG;Urban S;Guo JT;Locarnini S;Zoulim F;Chang KM;Lok AS
乙型肝炎病毒 (HBV) 是一种重要的全球病原体，感染全球超过 2.4 亿人。尽管乙型肝炎的治疗已有所改善，但乙型肝炎患者通常需要终生治疗，治愈仍然是一个具有挑战性的目标。技术和制药科学的最新进展预示着创新治疗方法的新视野，使我们更接近功能性治愈慢性乙型肝炎病毒感染的可能性。在本文中，我们回顾了乙型肝炎治疗的科学现状，并重点介绍了由最新科学进展推动的新的、令人兴奋的治疗策略。其中一些疗法已经进入临床阶段，我们可能会看到更多的疗法正在开发中。随着人们对开发更有效的乙型肝炎疗法的兴趣日益浓厚并付出努力，治愈这一具有挑战性的目标可能在不久的将来就可以实现。
Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients often require life-long therapies and cure is still a challenging goal. Recent advances in technologies and pharmaceutical sciences have heralded a new horizon of innovative therapeutic approaches that are bringing us closer to the possibility of a functional cure of chronic HBV infection. In this article, we review the current state of science in HBV therapy and highlight new and exciting therapeutic strategies spurred by recent scientific advances. Some of these therapies have already entered into clinical phase and we will likely see more of them moving along the development pipeline. With a growing interest in and effort to developing more effective therapies for HBV, the challenging goal of a cure may be well within reach in the near future.