Are two really better than one? Empirical examination of repeat blood pressure measurements and stroke risk in the Renfrew/Pitisley and collaborative studies
Are two really better than one? Empirical examination of repeat blood pressure measurements and stroke risk in the Renfrew/Pitisley and collaborative studies
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DOI：
10.1161/hs1101.098637
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发表时间：
2001-11-01
期刊：
影响因子：
8.3
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Hart, CL;Hole, DJ;Smith, GD
背景和目的-在苏格兰的两项大型前瞻性队列研究中，两次测量的血压与中风有关，定义为中风死亡率或中风住院。研究的目的是调查2次血压读数是否能比1次血压读数更准确地估计长期内中风的风险。方法：在20世纪70年代，Renfrew/Paisley总体人口研究调查了3060名男性和3502名女性，而Collaborative研究调查了2次2683名受雇男性。平均筛查间隔时间分别为4年和5年。两次测量的血压分别与第二次筛查后17年和21年随访期的卒中风险相关。结果：对于两次测量的收缩压和舒张压，两次测量的平均值、两次测量中的最大值和经回归稀释校正的测量与随访期间的卒中风险的相关性比两次测量中的任一次测量更强。结论：两次测量的血压似乎都比1更能指示中风的风险。使用单一衡量标准的低估将导致对个人疾病风险的错误分类，也会导致与高血压相关的疾病的人群归因性风险。
Background and Purpose-Blood pressure measured on 2 occasions in 2 large prospective cohort studies in Scotland was related to stroke, defined as stroke mortality or hospital admission for stroke. The purpose was to investigate whether 2 blood pressure readings gave a more accurate estimate of stroke risk over a long follow-up period than 1 reading.Methods-In the 1970s, the Renfrew/Paisley general population study investigated 3060 men and 3502 women and the Collaborative study investigated 2683 employed men on 2 occasions. The mean years between screening were 4 and 5, respectively. Blood pressure measured on the 2 occasions was related to stroke risk in 17-year and 21-year follow-up periods after the second screening, respectively.Results-For both systolic and diastolic blood pressure, the mean of the measures on the 2 occasions, the maximum of the 2 measures and the measure corrected for regression dilution was more strongly related to stroke over the follow-up periods than either single measure.Conclusions-Two blood pressure measurements seem better than 1 for indicating stroke risk. Underestimation using single measures will lead to both misclassification of the risk of disease for individuals and also the population-attributable risk of disease associated with elevated blood pressure.