Prevalence of infectious keratitis in Central China.
Prevalence of infectious keratitis in Central China.
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DOI：
10.1186/1471-2415-14-43
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发表时间：
2014-04-02
影响因子：
2
通讯作者：
Tan X
中科院分区：
文献类型：
--
作者：
Cao J;Yang Y;Yang W;Wu R;Xiao X;Yuan J;Xing Y;Tan X
我国传染性角膜炎流行病学调查的基线数据仍然匮乏，目前国家还没有制定角膜失明控制策略。采用按地域整群抽样的方法，从湖北省城乡代表性人群中随机抽取横截面居民。参与者是从村庄登记册中挑选出来的，然后挨家挨户走访。评估项目包括结构化访谈、视力测试、外眼检查和裂隙灯眼前节检查。根据统一的定制方案确定角膜疾病的原因和后遗症。角膜疾病患病率为0.8%（211/26 305），感染性角膜炎患病率为0.148%（39/26 305）。病毒性、细菌性和真菌性角膜炎的患病率分别为0.065%、0.068%和0.015%。病毒性（占43.6%）和细菌性（占46.2%）角膜溃疡的患病率没有显着差异。未发现棘阿米巴角膜炎病例。感染性角膜炎是角膜失明的主要原因（85.7%），至少一只眼睛因感染角膜而失明的患病率为0.091%（95% CI：0.067-0.127%）。病毒和细菌机制构成华中地区感染性角膜溃疡最重要的危险因素。为了降低感染性角膜炎的发病率和严重程度，公共卫生保健政策应侧重于设计具有成本效益的策略和操作计划，以预防和及时治疗感染性角膜溃疡。
The baseline data pertaining to the national epidemiological survey of infectious keratitis remain scarce in China, and currently there is no corneal blindness control strategy developed by the nation. Geographically defined cluster sampling was used to randomly select a cross-section of residents from representative urban and rural populations in Hubei Province. Participants were selected from village registers, followed by door-to-door household visits. The assessment items included a structured interview, visual acuity testing, external eye examination, and anterior segment examination using slit lamp. Causes and sequelae of corneal disease were identified according to uniform customized protocol. The prevalence of presenting corneal diseases was 0.8% (211/26 305), while the prevalence of infectious keratitis was 0.148% (39/26 305). The prevalences of viral, bacterial, and fungal keratitis were 0.065, 0.068, and 0.015%, respectively. There were no significant differences found between the prevalences of viral (accounting for 43.6%) and bacterial (accounting for 46.2%) corneal ulcers. cases of Acanthamoeba keratitis were not found. Infectious keratitis was the leading cause of corneal blindness (85.7%), and the prevalence of blindness in at least one eye resulting from infected corneas was 0.091% (95% CI: 0.067-0.127%). Viral and bacterial mechanisms constitute the most important risk factors for infectious corneal ulcers in Central China. To reduce the rate and severity of infectious keratitis, he public health care policy should be focused on designing cost-effective strategies and operational programs for the prevention and prompt treatment of infectious corneal ulcers.
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影响因子：
34.3
作者：
Bourne, Rupert R. A.;Stevens, Gretchen A.;Taylor, Hugh R.
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
3.9
作者：
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通讯作者：
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3.9
作者：
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Wong, E