Does colorectal cancer clinical advancement affect adhesion molecules (sP- selectin, sE- selectin and ICAM-1) concentration?
Does colorectal cancer clinical advancement affect adhesion molecules (sP- selectin, sE- selectin and ICAM-1) concentration?
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DOI：
10.1016/j.thromres.2008.11.021
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发表时间：
2009-05-01
影响因子：
7.5
通讯作者：
Kemona, H.
中科院分区：
文献类型：
--
作者：
Dymicka-Piekarska, V.;Kemona, H.
粘附分子参与生理和病理过程。它们参与炎症反应，在肿瘤侵袭和转移发展中发挥重要作用。本研究在结直肠癌患者中发现了P-选择素、E-选择素和ICAM-1的可溶性形式。采用酶联免疫吸附试验（ELISA）从44例结直肠癌患者和34例对照组患者的既往手术中获得血浆。根据TNM分型对患者进行分组。结直肠癌患者血浆中这三种分子水平均显著高于对照组（p < 0.001）。肝转移患者中sE-选择素和ICAM-1水平最高。sP-选择素与sE-选择素之间没有相关性，但我们发现sE-选择素与ICAM-1在所有患者中均有显著相关性。这些发现提示血浆E-选择素和ICAM-1的浓度可能指示肿瘤的进展和肝转移。(C) 2008 Elsevier Ltd版权所有。
Adhesion molecules take part in physiological and pathological processes. They involved in inflammatory reactions and play important role in tumor invasion and the development of metastases.Soluble forms of P- selectin, E- selectin and ICAM-1 have been described in this study in patient with colorectal cancer. Plasma was obtained from 44 patients with colorectal cancer and 34 control subject's prior surgery, by an enzyme- linked immunosorbent assay (ELISA). The patients were divided according to TNM classification.Plasma level of all three molecules was significantly higher in colorectal cancer patients than in the control (p < 0.001). The highest level of sE- selectin and ICAM-1 were observed in patients with liver metastasis. There was no correlation between sP- selectin and sE- selectin, but we found a significant correlation between sE- selectin and ICAM-1 in all patients.These findings suggest that plasma concentration of E- selectin and ICAM-1 may indicate tumor progression and liver metastasis. (C) 2008 Elsevier Ltd. All rights reserved.