Sites of acetylation of sickle cell hemoglobin by aspirin.
Sites of acetylation of sickle cell hemoglobin by aspirin.
复制标题
阿司匹林对镰状细胞血红蛋白的乙酰化位点。
DOI：
10.1073/pnas.71.12.4693
复制
发表时间：
1974
影响因子：
11.1
通讯作者：
I. M. Klotz
中科院分区：
文献类型：
--
作者：
M. Shamsuddin;R. Mason;J. M. Ritchey;G. Honig;I. M. Klotz
Aspirin acetylates a variety of sites on both the alpha and beta chains of hemoglobin S. Nevertheless, the vast majority of acetyl groups become attached to three loci: betaLys 59, betaLys 144, and alphaLys 90. These observations reveal some molecular details of this transacylation reaction and suggest interesting possibilities for its extension to other acylsalicylates with a variety of different structures.
