Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic
Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic
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DOI：
10.1002/jcb.24708
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发表时间：
2014-04-01
影响因子：
4
通讯作者：
Chen, Yan
中科院分区：
文献类型：
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作者：
Cai, Yu;Cai, Tiange;Chen, Yan
骨肉瘤是儿童和青少年最常见的恶性骨肿瘤。虽然这种疾病的病理特征是明确和完善的，但对于这种肿瘤，特别是在分子信号水平上，仍有许多有待了解的地方。Wnt家族的分泌信号分子已被广泛研究，并被发现在控制胚胎骨发育、骨量和出生后骨再生中发挥核心作用。各种研究也表明Wnt信号通路与骨恶性肿瘤密切相关，包括乳腺癌或前列腺癌诱导的骨转移、多发性骨髓瘤以及骨肉瘤。在这里，我们概述了Wnt信号通路在骨肉瘤发生和进展中的作用，并强调了Wnt通路在这种骨恶性肿瘤中的异常激活。我们还讨论了靶向Wnt通路治疗骨肉瘤的潜在治疗应用。j .细胞。中国生物医学工程学报，2014,31(2):625-631。(c) 2013 Wiley Periodicals, Inc.；
Osteosarcoma is the most common malignant bone tumor in children and adolescents. Although pathologic characteristics of this disease are clear and well established, much remains to be understood about this tumor, particularly at the molecular signaling level. Secreted signaling molecules of the Wnt family have been widely investigated and found to play a central role in controlling embryonic bone development, bone mass, and postnatal bone regeneration. A variety of studies also suggest that Wnt signaling pathway is closely associated with bone malignancies, including breast or prostate cancer induced bone metastasis, multiple myeloma, as well as osteosarcoma. Here, we provide an overview of the role of Wnt signaling pathway in osteosarcoma development and progression, highlighting the aberrant activation of Wnt pathway in this bone malignancy. We also discuss the potential therapeutic applications for the treatment of osteosarcoma targeting Wnt pathway. J. Cell. Biochem. 115: 625-631, 2014. (c) 2013 Wiley Periodicals, Inc.