Prediction of many new exons and introns in Plasmodium falciparum chromosome 2

Prediction of many new exons and introns in Plasmodium falciparum chromosome 2
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DOI:
10.1016/s0166-6851(01)00376-0
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发表时间:
2001-12-01
影响因子:
1.5
通讯作者:
Fischer, K
Fischer, K
中科院分区:
医学4区
文献类型:
--
作者:
Huestis, R;Fischer, K

文献摘要

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目前的预测或恶性疟原虫基因组数据库中的基因依赖于有限数量的专门开发的计算机算法。我们通过计算机辅助手动分析重新注释了恶性疟原虫2号染色体的序列。这是在这里描述的。在 161 个新预测的内含子中,我们通过实验证实了 98 个。我们认为先前发表的分析中的 110 个内含子是可能的,我们删除了 3 个,改变了 26 个并添加了 135 个。我们识别了 2 号染色体中的 214 个基因。我们预测了 121 个基因中的内含子。 2 号染色体上增加的复杂性或基因结构很可能反映在整个基因组中。 (C) 2001 Elsevier Science B.V. 保留所有权利。
The current prediction or genes in the Plasmodium falciparum genome database relies upon a limited number of specially developed computer algorithms. We have re-annotated the sequence of chromosome 2 of P. falciparum by a computer-assisted manual analysis. which is described here. Of 161 newly predicted introns, we have experimentally confirmed 98. We regard 110 introns from the previously published analyses as probable, we delete 3, change 26 and add 135. We recognise 214 genes in chromosome 2. We have predicted introns in 121 genes. The increased complexity or gene structure on chromosome 2 is likely to be mirrored by the entire genome. (C) 2001 Elsevier Science B.V. All rights reserved.