Cryptococcus neoformans: virulence and host defences.
Cryptococcus neoformans: virulence and host defences.
复制标题
新型隐球菌：毒力和宿主防御。
作者：
J. R. Perfect;Brian Wong;Yun C. Chang;Kyung J. Kwon‐Chung;P. Williamson
新型隐球菌代表了研究毒力和宿主反应的模式生物。在这个讨论中，有一个集中的遗传，分子和生物化学方面的C。与宿主相互作用的过程中直接和间接毒力表型的调查现在是可能的。两个主要的毒力因子，胶囊和黑色素的分子方面的特点。通过甘露醇的酵母多元醇代谢作为一个潜在的生物化学途径的毒力。C.的概念在宿主内或响应于某些环境线索的新形虫差异表达的基因可间接用于鉴定潜在的毒力基因。然而，尽管在C.由于新形式的人的存在，这一领域研究的未来将需要一定数量的研究人员，以帮助分担继续发生的发展成本。
Cryptococcus neoformans represents a model organism for the study of virulence and the host response. In this discussion, there is a focus on the genetic, molecular, and biochemical aspects of C. neoformans as it interacts with the host. Investigations into direct and indirect virulence phenotypes are now possible. The molecular aspects of two major virulence factors, capsule and melanin, are characterized. Yeast polyol metabolism through mannitol is examined as a potential biochemical pathway for virulence. The concept of C. neoformans differentially expressed genes within the host or in response to certain environmental cues can be used indirectly to identify potential virulence genes. However, despite significant progress in molecular pathogenesis with C. neoformans, the future of research in this area will require a certain critical mass of investigators to help share in the developmental costs which continue to occur.