A data repository and analysis framework for spontaneous neural activity recordings in developing retina.
A data repository and analysis framework for spontaneous neural activity recordings in developing retina.
复制标题
DOI：
10.1186/2047-217x-3-3
复制
发表时间：
2014-03-26
期刊：
影响因子：
9.2
通讯作者：
Sernagor E
中科院分区：
文献类型：
--
作者：
Eglen SJ;Weeks M;Jessop M;Simonotto J;Jackson T;Sernagor E
在早期发育过程中，神经回路自发放电，产生具有复杂时空模式的活动片段。在过去的25年里，神经系统的许多部分都记录了自发活动，报告了活动模式的发育变化和各种遗传扰动的影响。我们提出了一个多电极阵列记录发育中的小鼠和雪貂视网膜自发活动的资料库。这些数据已经用最少的元数据进行了注释，并转换为HDF5。本文描述了这些数据的结构，以及使用这些数据文件进行可重复性研究的例子。我们还演示了如何在卡门工作流系统中分析这些数据。本文是以识字编程文档编写的；这里描述的所有程序和数据都是免费提供的。1.我们希望这个资料库将导致对不同实验室记录的自发活动进行新的分析。2.我们鼓励将已发布的数据添加到存储库。3.该资料库是如何储存多电极阵列记录以供长期重复使用的范例。
During early development, neural circuits fire spontaneously, generating activity episodes with complex spatiotemporal patterns. Recordings of spontaneous activity have been made in many parts of the nervous system over the last 25 years, reporting developmental changes in activity patterns and the effects of various genetic perturbations. We present a curated repository of multielectrode array recordings of spontaneous activity in developing mouse and ferret retina. The data have been annotated with minimal metadata and converted into HDF5. This paper describes the structure of the data, along with examples of reproducible research using these data files. We also demonstrate how these data can be analysed in the CARMEN workflow system. This article is written as a literate programming document; all programs and data described here are freely available. 1. We hope this repository will lead to novel analysis of spontaneous activity recorded in different laboratories. 2. We encourage published data to be added to the repository. 3. This repository serves as an example of how multielectrode array recordings can be stored for long-term reuse.