Impact of the matrix metalloproteinase MMP-3 on dementia
Impact of the matrix metalloproteinase MMP-3 on dementia
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DOI：
10.1016/j.neurobiolaging.2006.05.030
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发表时间：
2007-08-01
影响因子：
4.2
通讯作者：
Amouyel, Philippe
中科院分区：
文献类型：
--
作者：
Helbecque, Nicole;Cottel, Dominique;Amouyel, Philippe
P-淀粉样肽（Aβ）在大脑中的积累是阿尔茨海默病（AD）发病机制中的一个核心事件。几种蛋白酶在体外或基于细胞的测定中被证明可以水解 Aβ，并且可能是在大脑中 Aβ 清除中发挥作用的候选酶。先前的报告表明基质金属蛋白酶（MMP）可能参与这种机制。两项独立研究对 MMP-3 1171 (5A/6A) 位点的功能多态性进行了检查，以调查该多态性对患痴呆症风险的影响。我们发现，APOE epsilon 4 非携带者和 MMP-3 多态性 6A/6A 纯合子受试者患痴呆症的风险增加。我们的研究结果支持 MMP 可能影响痴呆风险的假设。 (c) 2006 Elsevier Inc. 保留所有权利。
Cerebral accumulation of P-amyloid peptide (A beta) is a central event in the pathogenesis of Alzheimer's disease (AD). Several proteases were shown to hydrolyze A beta in vitro or in cell-based assays, and are likely candidates for a role in A beta clearance in brain. Previous reports suggest that matrix metalloproteinases (MMPs) could be involved in such a mechanism. A functional polymorphism at position - 1171 (5A/6A) in MMP-3 was examined in two independent studies to investigate the impact of this polymorphism on the risk of developing dementia. We found that subjects APOE epsilon 4 non-carriers and 6A/6A homozygous for the MMP-3 polymorphism were at increased risk of dementia. Our findings support the hypothesis that MMPs may influence the risk of dementia. (c) 2006 Elsevier Inc. All rights reserved.