DIFFERENTIAL INHIBITION OF KETOGENESIS BY MALONYL-COA IN MITOCHONDRIA FROM FED AND STARVED RATS
DIFFERENTIAL INHIBITION OF KETOGENESIS BY MALONYL-COA IN MITOCHONDRIA FROM FED AND STARVED RATS
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DOI：
10.1042/bj1920955
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发表时间：
1980-01-01
影响因子：
4.1
通讯作者：
CORNELL, NW
中科院分区：
文献类型：
--
作者：
COOK, GA;OTTO, DA;CORNELL, NW
在最佳底物浓度下，进食或饥饿大鼠线粒体中的生酮速率相同，但对丙二酰辅酶A的抑制反应不同。丙二酰辅酶A的Ki在饥饿动物中明显更高。对于在饥饿状态下酮生成的调节，肉毒碱棕榈酰转移酶对丙二酰辅酶A抑制的较低敏感性可能比丙二酰辅酶A的浓度更重要。
Rates of ketogenesis in mitochondria from fed or starved rats were identical at optimal substrate concentrations, but responded differently to inhibition by malonyl-CoA. The Ki for malonyl-CoA is apparently greater in the starved animal. For the regulation of ketogenesis in the starved state, the lower sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA may be more important than the concentration of malonyl-CoA.