Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer.
Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer.
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DOI：
10.1007/978-3-031-06573-6_23
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发表时间：
2022
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肌动蛋白是哺乳动物中高度保守的蛋白质。肌动蛋白动力学受肌动蛋白结合蛋白和肌动蛋白相关蛋白的调节。核肌动蛋白和这些调节蛋白参与多个核过程，包括染色体结构组织、染色质重塑、转录机制调节和DNA修复。众所周知，这些过程的功能障碍有助于癌症的发展。此外，新出现的证据表明，肌动蛋白动力学失调也与癌症有关。本章讨论了核肌动蛋白动力学的失调如何通过各种核事件促进肿瘤发生。
Actin is a highly conserved protein in mammals. The actin dynamics is regulated by actin-binding proteins and actin-related proteins. Nuclear actin and these regulatory proteins participate in multiple nuclear processes, including chromosome architecture organization, chromatin remodeling, transcription machinery regulation, and DNA repair. It is well known that the dysfunctions of these processes contribute to the development of cancer. Moreover, emerging evidence has shown that the deregulated actin dynamics is also related to cancer. This chapter discusses how the deregulation of nuclear actin dynamics contributes to tumorigenesis via such various nuclear events.