Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.
Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.
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DOI：
10.1016/j.molimm.2018.01.014
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发表时间：
2019-06
影响因子：
3.6
通讯作者：
Li HS
中科院分区：
文献类型：
--
作者：
Chrisikos TT;Zhou Y;Slone N;Babcock R;Watowich SS;Li HS
树突状细胞（Dendritic cells，DCs）是免疫系统中主要的抗原提呈细胞，在免疫耐受和免疫激活中起着关键作用。因此，DC是肿瘤免疫的主要介质。DC可以调节致耐受性免疫应答，促进不受抑制的肿瘤生长。然而，重要的是，DC还介导抑制肿瘤进展的免疫刺激活性。例如，新出现的证据表明cDC 1亚群在将肿瘤抗原递送至淋巴结和诱导针对肿瘤的抗原特异性淋巴细胞应答中具有重要功能。此外，DC控制癌症中的特异性治疗应答，包括由免疫检查点阻断引起的那些。DC的产生和功能受到细胞因子及其细胞内信号蛋白（包括STAT转录因子）的深刻影响。无论如何，我们对富含精氨酸的肿瘤微环境中DC调节的理解仍在发展中，必须更好地定义以推进癌症治疗。在这里，我们回顾文献集中在DC的分子控制，特别强调细胞因子和STAT介导的DC调节。此外，我们强调了最近的研究，描绘了DC在抗肿瘤免疫和免疫治疗中的重要性，总体目标是提高对肿瘤相关因子和影响DC在癌症中功能的内在DC信号级联的认识。
Dendritic cells (DCs) are the principal antigen-presenting cells of the immune system and play key roles in controlling immune tolerance and activation. As such, DCs are chief mediators of tumor immunity. DCs can regulate tolerogenic immune responses that facilitate unchecked tumor growth. Importantly, however, DCs also mediate immune-stimulatory activity that restrains tumor progression. For instance, emerging evidence indicates the cDC1 subset has important functions in delivering tumor antigens to lymph nodes and inducing antigen-specific lymphocyte responses to tumors. Moreover, DCs control specific therapeutic responses in cancer including those resulting from immune checkpoint blockade. DC generation and function is influenced profoundly by cytokines, as well as their intracellular signaling proteins including STAT transcription factors. Regardless, our understanding of DC regulation in the cytokine-rich tumor microenvironment is still developing and must be better defined to advance cancer treatment. Here, we review literature focused on the molecular control of DCs, with a particular emphasis on cytokine- and STAT-mediated DC regulation. In addition, we highlight recent studies that delineate the importance of DCs in anti-tumor immunity and immune therapy, with the overall goal of improving knowledge of tumor-associated factors and intrinsic DC signaling cascades that influence DC function in cancer.
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影响因子：
20.3
作者：
Capitini, Christian M.;Nasholm, Nicole M.;Fry, Terry J.
通讯作者：
Fry, Terry J.
DOI：
10.1097/aci.0000000000000322
发表时间：
2016-12
影响因子：
2.8
作者：
Bigley V;Barge D;Collin M
通讯作者：
Collin M
DOI：
10.4161/jkst.23931
发表时间：
2013-07-01
期刊：
JAK-STAT
影响因子：
--
作者：
Au-Yeung N;Mandhana R;Horvath CM
通讯作者：
Horvath CM
影响因子：
32.4
作者：
Butte, Manish J.;Keir, Mary E.;Freeman, Gordon J.
通讯作者：
Freeman, Gordon J.
内源性转化生长因子β1在Langerhans细胞生物学中的作用：转化生长因子β1空小鼠的皮肤没有表皮Langerhans细胞。
DOI：
10.1084/jem.184.6.2417
发表时间：
1996-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
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