Bilaterally Diffuse Lacrimal Gland Involvement: Initial Presentation of Systemic Sarcoidosis
Bilaterally Diffuse Lacrimal Gland Involvement: Initial Presentation of Systemic Sarcoidosis
复制标题
DOI：
10.4274/tjo.89310
复制
发表时间：
2017-06-01
影响因子：
1.1
通讯作者：
Kaygusuz, Gulsah
中科院分区：
文献类型：
--
作者：
Kiziltunc, Pinar Bingol;Ciftci, Fatma;Kaygusuz, Gulsah
系统性结节病累及眼眶的情况很少见。我们报告一例以双侧巨大泪腺受累为首发表现的眼眶结节病。一名20岁女性因双侧上眼睑进行性肿胀6个月入院眼科。唯一的病理发现是在泪腺位置的上眼睑外侧存在双侧对称的实性小叶状肿块。全身检查发现双侧腮腺和颌下腺肿胀。眼眶磁共振成像显示双侧泪腺对称弥漫性增大，最大厚度为 11 毫米，最小厚度为 7 毫米。活检结果与结节病相符。虽然泪腺受累已在不同的研究中报道，但我们首次报道双侧弥漫性巨大泪腺受累的罕见病例。磁共振成像正常泪腺厚度约为4-5毫米，而本例患者双侧泪腺弥漫性肿大，最大厚度为11毫米，最小厚度为7毫米。尽管结节病中眼眶受累并不常见，但在眼眶肿块的鉴别诊断中应记住这一点。
Orbital involvement in systemic sarcoidosis is a rare condition. We report a case of orbital sarcoidosis with bilaterally huge lacrimal gland involvement as the initial manifestation of systemic sarcoidosis. A 20-year-old woman admitted the ophthalmology department with progressive bilateral upper eyelid swelling for 6 months. The only pathologic finding was the presence of bilateral, symmetrical, solid, lobular masses at the lateral upper eyelids at the location of lacrimal glands. On systemic examination, bilateral parotid and submandibular glands appeared swollen. Magnetic resonance imaging of the orbit revealed bilateral symmetrical diffuse enlargement of the lacrimal glands with maximum and minimum thickness of 11 mm and 7 mm, respectively. The biopsy findings were compatible with sarcoidosis. Although lacrimal gland involvement has been reported in different studies, we for the first time report an unusual case with bilateral diffuse huge lacrimal gland involvement. Normal lacrimal gland thickness is approximately 4-5 mm in magnetic resonance imaging, while our case had bilateral diffuse enlargement of lacrimal glands, which showed maximum and minimum thickness of 11 mm and 7 mm, respectively. Although orbital involvement is uncommon in sarcoidosis, it should be remembered in the differential diagnosis of orbital masses.