Total Synthesis of (+)-Lysergic Acid
Total Synthesis of (+)-Lysergic Acid
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DOI：
10.1021/ol2018467
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发表时间：
2011-09-16
期刊：
影响因子：
5.2
通讯作者：
Jia, Yanxing
中科院分区：
文献类型：
--
作者：
Liu, Qiang;Jia, Yanxing
A stereocontrolled total synthesis of (+)-lysergic acid (1) is achieved using three metal-catalyzed methodologies for the construction of three key rings. Highlights of the synthesis include Pd-catalyzed indole synthesis to form the Bring, a RCM reaction to form the D ring, and an intramolecular Heck reaction to form the C ring.
