ORP150 ameliorates ischemia/reperfusion injury from middle cerebral artery occlusion in mouse brain
ORP150 ameliorates ischemia/reperfusion injury from middle cerebral artery occlusion in mouse brain
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DOI：
10.1016/j.brainres.2004.04.058
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发表时间：
2004-07-23
期刊：
影响因子：
2.9
通讯作者：
Matsuyama, T
中科院分区：
文献类型：
--
作者：
Kitano, H;Nishimura, H;Matsuyama, T
150 kDa氧调节蛋白(OPP150)是一种定位于内质网(ER)的新的应激蛋白，受缺氧/缺血诱导。为探讨ORP150在脑缺血/再灌注后脑梗塞中的作用，对ORP150转基因(TG)和基因敲除(KO)小鼠进行大脑中动脉(MCA)阻断1或3h后再灌流24 h，再灌注1h后，OPP150转基因(TG)和敲除(KO)小鼠大脑皮质梗死体积明显小于ORP150KO小鼠(P
The 150-kDa oxygen-regulated protein (OPP150), a novel stress protein localized to the endoplasmic reticulum (ER), is induced by hypoxia/ischemia. To determine the role of ORP150 in cerebral infarction following ischemia/reperfusion, ORP150 transgenic (TG) and knockout (KO) mice were subjected to 1 or 3 h of middle cerebral artery (MCA) occlusion followed by reperfusion for 24 h. At 24 h after 1 h of occlusion, significantly less infarct volume was evident in cerebral cortex, but not in striatum, in OPP150TG than ORP150KO mice (P