Effects of self-administered alcohol concentration on the frequency and persistence of rats' attending to alcohol cues.
Effects of self-administered alcohol concentration on the frequency and persistence of rats' attending to alcohol cues.
复制标题
自我注射酒精浓度对大鼠注意酒精线索的频率和持续性的影响。
DOI：
10.1097/00008877-200605000-00001
复制
发表时间：
2006
影响因子：
1.6
通讯作者：
Jimenez-Gomez,Corina
中科院分区：
文献类型：
--
作者：
Shahan,TimothyA;Jimenez-Gomez,Corina
观察反应产生与待辨别的刺激的接触，并且被认为是注意的动物模型。在观察-反应程序中，一种反应的药物可用性与消退的交替周期不发出信号，但第二种反应（即观察反应）产生刺激信号，表明药物是否可用。本实验考察了自饮酒精浓度和增加观察反应要求对大鼠观察酒精刺激的影响。此外，当酒精不再可用时，研究了酒精浓度对观察持续性的影响。结果表明，观察跟踪的双调变化的酒精交付的数量，而不是单调增加的酒精消费总量增加酒精浓度的增加。增加观察反应的要求，减少了刺激介绍赚取的数量。在酒精刺激的存在下所花费的时间的减少与酒精消费的减少有关。在酒精反应消退期间，当它产生先前与较高酒精浓度相关的刺激时，观察更加持久。最后，响应酒精是更耐灭绝的观察反应产生的酒精刺激的存在下，而不是在它的情况下，但不依赖于酒精浓度。这些结果表明，获得酒精线索的难度增加，可以通过减少与这些线索的接触来减少酒精消费。此外，如果在本程序中观察行为类似于参加酒精线索，结果表明，参加酒精线索是更持久的线索，以前与较高的剂量，并参加酒精线索的持久性及其对饮酒的影响可能是可分离的。
Observing responses produce contact with stimuli that are to be discriminated and have been considered an animal model of attending. In the observing-response procedure, alternating periods of drug availability versus extinction for one response are not signaled, but a second response (ie the observing response) produces stimuli signaling whether drug is available or not. This experiment examined the effects of the concentration of self-administered alcohol and increases in observing-response requirement on rats' observing alcohol stimuli. In addition, the effects of alcohol concentration on the persistence of observing were examined when alcohol was no longer available. Results showed that observing tracked bitonic changes in the number of alcohol deliveries rather than monotonic increases in total alcohol consumption resulting from increases in alcohol concentration. Increasing the observing-response requirement decreased the number of stimulus presentations earned. The resultant decreases in time spent in the presence of the alcohol stimulus were associated with decreases in alcohol consumption. During extinction of alcohol responding, observing was more persistent when it produced a stimulus previously associated with a higher alcohol concentration. Finally, responding for alcohol was more resistant to extinction in the presence of an observing-response-produced alcohol stimulus than in its absence, but did not depend on alcohol concentration. These results suggest that increases in the difficulty of obtaining access to alcohol cues can decrease alcohol consumption by reducing contact with those cues. In addition, if observing behavior in the present procedure is analogous to attending to alcohol cues, the results suggest that attending to alcohol cues is more persistent with cues previously associated with higher doses, and that the persistence of attending to alcohol cues and their impact on drinking may be dissociable.