INDUCTION OF PARTIAL IMMUNITY TO INFLUENZA BY A NEURAMINIDASE-SPECIFIC VACCINE
INDUCTION OF PARTIAL IMMUNITY TO INFLUENZA BY A NEURAMINIDASE-SPECIFIC VACCINE
复制标题
DOI：
10.1093/infdis/129.4.411
复制
发表时间：
1974-01-01
影响因子：
6.4
通讯作者：
KILBOURNE, ED
中科院分区：
文献类型：
--
作者：
COUCH, RB;KASEL, JA;KILBOURNE, ED
用X-32(Heqln2)灭活疫苗对成年志愿者进行肠外免疫，诱导产生抗H3N2型流感病毒神经氨酸酶抗体。随后，接种疫苗的志愿者和对照组男性接受了甲型H3N1亚型活病毒的鼻腔攻击。虽然对照组和疫苗接种组的感染频率没有明显差异，但接种X-32疫苗的志愿者的发病率显著降低。现有志愿者的再次挑战显示，在第一次挑战期间感染X-32疫苗的男子得到了完全保护。这些观察表明，管理。神经氨酸酶特异性灭活病毒疫苗可以诱导对感染含有抗原性相同神经氨酸酶抗原的流感病毒引起的疾病的保护，并且发生的感染诱导对抗原性相似病毒的后续攻击的抵抗力。
Antibody to the neuraminidase antigen of influenza A/Hong Kong (H3N2) virus was induced in adult volunteers by parenteral immunization with inactivated X-32 (HeqlN2) vaccine. Subsequently, vaccinated volunteers and a control group of men were challenged intranasally with live A/Hong Kong virus (H3N2). While the frequencies of infection in control and vaccinated groups were not significantly different, the incidence of illness in volunteers who received X-32 vaccine was significantly reduced. Rechallenge of available volunteers demonstrated complete protection of men vaccinated with X-32 who had been infected during the first challenge. These observations indicate that administration of. a neuraminidase-specific inactivated virus vaccine can induce protection against illness caused by infection with influenza virus containing an antigenically identical neuraminidase antigen and that the infection that occurs induces resistance to subsequent challenge with antigenically similar virus.