Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men
Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men
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DOI：
10.1210/jc.2006-0382
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发表时间：
2006-12-01
影响因子：
5.8
通讯作者：
Stich, V.
中科院分区：
文献类型：
--
作者：
Klimcakova, E.;Polak, J.;Stich, V.
背景：肥胖的特征是一种低度炎症状态，这可能在胰岛素抵抗中发挥作用。目的：探讨动态力量训练对肥胖者的胰岛素增敏作用是否与血浆中可能参与胰岛素抵抗的脂肪因子水平和基因表达的变化有关。设计：对12名肥胖男性受试者进行为期3个月的动态力量训练。采用正常血糖-高胰岛素钳夹技术评价胰岛素敏感性。取sc腹壁脂肪组织的血样和针吸活检标本。测定血浆和脂肪组织中脂联素、瘦素、IL-1β、IL-6和肿瘤坏死因子-6的mRNA水平。结果：训练后，大鼠全身葡萄糖降解率提高24%(P=0.04)。训练过程中体重没有变化。训练期间血浆瘦素水平(16.6+/-6.3 ng/ml比13.1+/-5.7 ng/ml)下降了21%(P<；0.02)，而其他脂肪因子和C-反应蛋白水平没有变化。受试者皮下脂肪组织中脂肪因子的基因表达在训练过程中未发生改变。结论：动态力量训练可提高肥胖受试者的全身胰岛素敏感性。胰岛素敏感性的增加与训练引起的血浆水平或脂肪组织脂肪因子基因表达的改变无关，这些脂肪因子被认为参与了胰岛素抵抗的发展。
Context: Obesity is characterized by a low-grade inflammatory state, which could play a role in insulin resistance. Dynamic strength training improves insulin sensitivity.Objective: The objective of this study was to investigate, in obese subjects, whether the insulin sensitizing effect of dynamic strength training is associated with changes in plasma levels and gene expression of adipokines potentially involved in the development of insulin resistance.Design: Twelve obese male subjects were investigated before and at the end of 3 months of dynamic strength training. Insulin sensitivity was evaluated using euglycemic-hyperinsulinemic clamp. Blood samples and needle biopsy samples of sc abdominal adipose tissue were obtained. The plasma levels and adipose tissue mRNA levels of adiponectin, leptin, IL-1 beta, IL-6, and TNF-6 were determined.Results: The training induced an increase in the whole-body glucose disposal rate by 24% (P = 0.04). The body weight was not altered during the training. Plasma levels of leptin decreased during the training (16.6 +/- 6.3 vs. 13.1 +/- 5.7 ng/ml) by 21% (P < 0.02), whereas no change in plasma levels of other adipokines and C-reactive protein was observed. Gene expression of the investigated adipokines was not changed in sc adipose tissue during the training.Conclusions: In obese subjects, the dynamic strength training resulted in an improvement of whole-body insulin sensitivity. The increase in insulin sensitivity was not associated with training-induced modifications of plasma levels or adipose tissue gene expression of adipokines supposedly involved in the development of insulin resistance.