Epidemiology, risk factors, and co-infection of vector-borne pathogens in goats from Sistan and Baluchestan province, Iran
Epidemiology, risk factors, and co-infection of vector-borne pathogens in goats from Sistan and Baluchestan province, Iran
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DOI：
10.1371/journal.pone.0218609
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发表时间：
2019-06-20
期刊：
影响因子：
3.7
通讯作者：
Asada, Masahito
中科院分区：
文献类型：
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作者：
Hakimi, Hassan;Sarani, Ali;Asada, Masahito
几种病媒传播的病原体限制了畜牧业，并在世界范围内产生重大经济影响。在流行地区，牲畜暴露于携带各种病原体的不同蜱种，这可能导致在单一宿主中合并感染几种蜱传播的病原体。虽然病原体的共感染和病原体之间的相互作用是决定疾病结果的关键因素，但对病原体在载体和宿主中的相互作用知之甚少。在这项研究中，我们调查了200只山羊从3个不同的地区在伊朗的Songs和俾路支斯坦省，羊巴氏泰勒虫，羊泰勒虫lestoquardi，羊无形体，嗜吞噬细胞无形体，边缘无形体的存在。种特异性诊断PCR和序列分析显示，1.5%、12.5%和80%的样品为T阳性。lestoquardi，T. ovis和A.羊，分别。在22%的样本中发现山羊与多达3种病原体的共感染。我们检测到T. ovis感染与年龄、T. ovis感染和位置（扎布尔），以及A.多因素Logistic回归分析绵羊感染与部位（Sarbaz）的相关性。此外，通过对山羊疟原虫感染数据的分析，发现山羊疟原虫感染与山羊疟原虫感染呈负相关。绵羊感染本研究有助于了解媒介传播的病原体的流行病学及其在山羊中的相互作用。
Several vector-borne pathogens restrict livestock farming and have significant economic impact worldwide. In endemic areas livestock are exposed to different tick species carrying various pathogens which could result in co-infection with several tick-borne pathogens in a single host. Although the co-infection of and the interaction among pathogens are critical factors to determine the disease outcome, pathogen interactions in the vector and the host are poorly understood. In this study, we surveyed the presence of Babesia ovis, Theileria ovis, Theileria lestoquardi, Anaplasma ovis, Anaplasma phagocytophilum, and Anaplasma marginale in 200 goats from 3 different districts in Sistan and Baluchestan province, Iran. Species-specific diagnostic PCRs and sequence analysis revealed that 1.5%, 12.5%, and 80% of samples were positive for T. lestoquardi, T. ovis, and A. ovis, respectively. Co-infections of goats with up to 3 pathogens were seen in 22% of the samples. We detected a significant association between T. ovis infection and age, T. ovis infection and location (Zabol), and A. ovis infection and location (Sarbaz) by multivariate logistic regression analysis. In addition, by analyzing the data with respect to Plasmodium caprae infection in these goats, a negative correlation was found between P. caprae and A. ovis infection. This study contributes to understanding the epidemiology of vector-borne pathogens and their interplay in goats.