Infectious disease risk factors of corneal graft donors
Infectious disease risk factors of corneal graft donors
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DOI：
10.1001/archophthalmol.2007.45
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发表时间：
2008-02-01
影响因子：
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通讯作者：
Varnum, Bruce H.
中科院分区：
文献类型：
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作者：
Hassan, Sohela S.;Wilhelmus, Kirk R.;Varnum, Bruce H.
目的：为了确定供体的健康状况如何影响角膜移植后感染的风险，方法：不良反应监测注册表被用来进行匹配的病例对照研究，从1994年1月1日至2003年12月31日之间移植供体角膜。病例包括162例穿透性角膜移植术后眼内炎的报告，包括121例微生物恢复，其中59例供体和受体微生物分离株一致。两个对照组按手术日期与每个病例相匹配。条件Logistic回归估计调整后的比值比与95%的置信区间，根据死亡前的状态donors.Results：角膜移植术后眼内炎与最近住院（比值比，2.84; 95%置信区间，1.61-4.98）和致命的癌症（比值比，2.46; 95%置信区间，1.53-3.97）之间的捐助者。捐赠后5天以上移植的组织更可能出现眼内炎（比值比，1.55; 95%置信区间，1.02-2.35）。供受者真菌性眼内炎的一致性微生物分离株检出率高于细菌性眼内炎（P
Objective: To determine how donor health status affects the risk of infection after corneal transplant.Methods: An adverse reaction surveillance registry was used to conduct a matched case-control study among transplanted donor corneas from January 1, 1994, to December 31, 2003. Cases comprised 162 reports of endophthalmitis after penetrating keratoplasty including 121 with microbial recovery, of which 59 had concordant donor and recipient microbial isolates. Two controls were matched to each case by surgery date. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals according to the premortem status of decedent donors.Results: Postkeratoplasty endophthalmitis was associated with recent hospitalization (odds ratio, 2.84; 95% confidence interval, 1.61-4.98) and fatal cancer (odds ratio, 2.46; 95% confidence interval, 1.53-3.97) among donors. Endophthalmitis appeared more likely with tissues transplanted longer than 5 days after donation (odds ratio, 1.55; 95% confidence interval, 1.02-2.35). The prevalence of concordant microbial isolates from donors and recipients was greater among fungal endophthalmitis than among bacterial endophthalmitis (P