Non‐invasive three‐dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage
Non‐invasive three‐dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage
复制标题
无创三维能量多普勒成像评估蛛网膜下腔出血小鼠模型的急性脑血流变化
DOI：
10.1111/1440-1681.13035
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发表时间：
2019
影响因子：
2.9
通讯作者：
Taki Yasuyuki
中科院分区：
文献类型：
--
作者：
Yamamoto Shuzo;Mutoh Tatsushi;Sasaki Kazumasu;Mutoh Tomoko;Tatewaki Yasuko;Taki Yasuyuki
我们的目的是评估在蛛网膜下腔出血（SAH）小鼠模型中使用高频功率多普勒超声成像非侵入性测量脑血流（CBF）方法的可行性。大脑中动脉区域脑体积内的 3 维 (3D) 重建血流信号（% 血管分布）与参考参数、基线颈动脉血流 (r2= 0.52，P<0.0001) 和标准化 CBF 变化 (r2= 0.74P<0.0001) 良好相关。这些数据表明，3D能量多普勒分析可能具有反映实验性SAH急性期实时CBF变化的潜力，这可能适用于早期脑损伤的临床前研究。
We aimed to evaluate the feasibility of a non‐invasive method of cerebral blood flow (CBF) measurement using high‐frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3‐dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r2= 0.52,P<0.0001) and normalized CBF changes (r2= 0.74P<0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real‐time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.