The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease
The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease
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HLA-DRB1等位基因对中国抗GBM疾病易感性的作用。
DOI：
10.1016/j.clim.2009.07.005
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发表时间：
2009-11-01
影响因子：
8.6
通讯作者：
Zhao, Ming-Hui
中科院分区：
文献类型：
--
作者：
Yang, Rui;Cui, Zhao;Zhao, Ming-Hui
抗肾小球基底膜病（GBM）是一种罕见的自身免疫性疾病，在高加索和日本人群中与HLA-DR15基因型相关。但HLA-DRB1等位基因在中国抗gbm患者中的分布及其与抗gbm临床特征的关系尚待确定。本研究对44例中国抗gbm患者和200例健康对照者的HLA-DRB1等位基因进行了序列分型分析。采用相对易感效应（relative predisposition effects, RPEs）方法检测DRB1等位基因对抗gbm疾病易感性的影响。收集并分析患者的临床及病理资料。DRB1*1501等位基因与抗gbm疾病显著相关（p = 1.597 × 10(-7)）。RPEs试验也显示DRB1*0404在抗gbm疾病中的频率显著增加（p=0.037）。有趣的是，携带DRB1*1501或*0404等位基因的患者肾小球月牙形成比不携带这两个等位基因的患者多（p=0.021）。但DRB1*0404在患者和对照组中都很少见，这表明*0404等位基因在抗gbm疾病中的重要性有限。我们得出结论，HLA-DRB1*1501等位基因是抗gbm疾病易感性的遗传标记。(C) 2009爱思唯尔公司版权所有。
Anti-glomerular basement membrane (GBM) disease, a rare autoimmune disorder, is associated with HLA-DR15 genotype in Caucasian and Japanese populations. But the distribution of HLA-DRB1 alleles in Chinese patients with anti-GBM disease and their association with clinical characteristics of anti-GBM disease are to be determined. The present study analyzed the HLA-DRB1 alleles by sequence based typing in 44 Chinese patients with anti-GBM disease and 200 healthy controls. The effects of DRB1 alleles on susceptibility to anti-GBM disease were examined by a relative predispositional effects (RPEs) method. The clinical and pathological data of the patients were collected and analyzed. The DRB1*1501 allele was significantly associated with anti-GBM disease (p = 1.597 x 10(-7)). The RPEs test also showed a significant increased frequency of DRB1*0404 in anti-GBM disease (p=0.037). Interestingly, the patients with DRB1*1501 or *0404 had more crescent formation in glomeruli than those without the two alleles (p=0.021). But the DRB1*0404 was rare in both patients and control groups, which indicates that the importance of the *0404 allele is limited in anti-GBM disease. We conclude that the HLA-DRB1*1501 allele is a genetic marker for susceptibility to anti-GBM disease. (C) 2009 Elsevier Inc. All rights reserved.