D-fining DarR: a LysR-type transcriptional regulator that responds to D-aspartate.
D-fining DarR: a LysR-type transcriptional regulator that responds to D-aspartate.
复制标题
D-fining DarR：一种对 D-天冬氨酸有反应的 LysR 型转录调节因子。
DOI：
10.1128/jb.00121-18
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发表时间：
2018
影响因子：
3.2
通讯作者：
Mandel,MarkJ
中科院分区：
文献类型：
--
作者：
Mandel,MarkJ
Jones et al.（R. M.小琼斯，D. L. Popham，A. L.施密特，E. L. Neidle和E. V. Stabb，J Bacteriol 200：e00773-17，2018，https：//doi.org/10.1128/jb.00773-17）描述了变形菌中的ad-天冬氨酸传感系统。d-氨基酸是肽聚糖和其他结构的关键组分。这项新的研究确定了LysR型转录调节因子DarR，它激活天冬氨酸消旋酶RacD。RacD的过表达使其能够在费氏弧菌突变体中合成谷氨酸并恢复正常的肽聚糖。这项研究有助于了解新出现的作用for-amino酸和它们是如何在不同的条件下合成。
Work by Jones et al. (R. M. Jones, Jr., D. L. Popham, A. L. Schmidt, E. L. Neidle, and E. V. Stabb, J Bacteriol 200:e00773-17, 2018, https://doi.org/10.1128/jb.00773-17) describes ad-aspartate-sensing system in proteobacteria.d-Amino acids are critical components of peptidoglycan and other structures. The new study identifies the LysR-type transcriptional regulator DarR, which activates the aspartate racemase RacD. The overexpression of RacD enables it to synthesized-glutamate and restore normal peptidoglycan in a Vibrio fischerimurImutant. This study contributes to the understanding of emerging roles ford-amino acids and how they are synthesized under distinct conditions.