NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population
NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population
复制标题
DOI：
10.1016/j.humimm.2009.04.026
复制
发表时间：
2009-09-01
期刊：
影响因子：
2.7
通讯作者：
Dicuonzo, Giordano
中科院分区：
文献类型：
--
作者：
Angeletti, Silvia;Galluzzo, Sara;Dicuonzo, Giordano
在本病例对照研究中，我们研究了CARD15 R702W、G908R和1007fs多态性在意大利胃癌患者中的潜在作用。研究人群包括170名胃癌患者和156名对照组。使用无条件回归（优势比和95%置信区间）来研究所研究的多态性与胃癌的关系。胃癌患者R702W和1007fs多态性的等位基因频率高于对照组（分别为8.53 vs 2.3和9.4 vs 0.7）。CARD15 R702W和1007fs多态性与胃癌发病率显著相关（p < 0.0001, p < 0.0001）。G908R单核苷酸多态性（SNP）分析未发现相关性。我们的研究报告了当CARD15编码区存在R702W和1007fs多态性时，意大利人群对胃癌的易感性增加。nod诱导的胃黏膜促炎细胞因子与环境致癌物的相互作用可能是CARD15基因多态性增加胃癌易感性的机制之一。这些snp的荟萃分析和NOD基因中其他多态性/单倍型的进一步分析将有助于确定它们在致癌作用中的作用。(C) 2009年美国组织相容性和免疫遗传学学会。Elsevier Inc.出版。版权所有。
In the present case-control Study we investigated the potential role of CARD15 R702W, G908R, and 1007fs polymorphisms in Italian gastric cancer patients. The study population consisted of 170 gastric cancer patients and 156 controls. Unconditional regression (odds ratios and 95% confidence interval) was used to investigate the association of the studied polymorphisms with gastric cancer. Higher allele frequencies of R702W and 1007fs polymorphisms were observed in patients with gastric cancer compared with controls (8.53 vs 2.3 and 9.4 vs 0.7, respectively). CARD15 R702W and 1007fs polymorphisms were significantly correlated with gastric cancer incidence (p < 0.0001, p < 0.0001, respectively). No correlation was found upon analyzing the G908R single nucleotide polymorphism (SNP). Our study reports an increased susceptibility to gastric cancer in Italian Populations when R702W and 1007fs polymorphisms in the coding region of CARD15 are present. The interaction between NOD-induced proinflammatory cytokines on gastric mucosa and environmental carcinogens could represent one of the mechanisms by which CARD15 polymorphisms increase the susceptibility to gastric cancer. Meta-analyses of these SNPs and further analyses of additional polymorphisms/haplotypes in NOD genes will help determine their role in carcinogenesis. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.