High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.
High Total Cholesterol in Peripheral Blood Correlates with Poorer Hearing Recovery in Idiopathic Sudden Sensorineural Hearing Loss.
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外周血中的高总胆固醇与特发性突然的感觉性听力损失的听力恢复较差相关。
DOI：
10.1371/journal.pone.0133300
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Sabbà C
中科院分区：
文献类型：
--
作者：
Quaranta N;Squeo V;Sangineto M;Graziano G;Sabbà C
特发性突发性感音神经性听力损失（ISSHL）是一种常见的耳科急症，其病因尚不清楚。血脂在ISSHL发病机制中的重要性已被文献广泛报道。事实上，低密度脂蛋白胆固醇（LDL）、总胆固醇（TC）和载脂蛋白B （Apo-B）水平升高已被认为是这种病理的危险因素。血脂参数与ISSHL的预后没有相关性。本研究的目的是确定与听力恢复相关的预后因素在一组受ISSHL影响的患者。本研究纳入2013年3月至2014年10月住院的94例诊断为ISSHL的患者。对患者进行血样和听力评估。根据患者对治疗的反应，将患者分为“康复”和“未康复”两组。我们发现，与康复组相比，未康复组的总胆固醇水平具有统计学意义（p = 0.03）。其他常规实验室参数均未显示成功治疗的患者与预后不良的患者之间有统计学上的显著差异。总胆固醇浓度可能是ISSHL患者康复的预后因素，应与患者的常规检查一起进行评估。其他常规实验室参数似乎对该病理的发展和预后没有影响。
Idiopathic sudden sensorineural hearing loss (ISSHL) is a common otologic emergency whose cause is still unclear. The importance of blood lipids in the pathogenesis of ISSHL is widely reported in literature. In fact elevated levels of low density lipoprotein cholesterol (LDL), total cholesterol (TC) and apolipoprotein B (Apo-B) have been proposed as risk factors for this pathology. No correlation has been described between serum lipid parameters and the prognosis of ISSHL. Aim of the present study was to identify prognostic factors associated with hearing recovery in a group of patients affected by ISSHL. Ninety-four patients with the diagnosis of ISSHL hospitalized between March 2013 and October 2014 were included in this study. Patients’ blood sampling and hearing assessments were carried out. Patients were divided into two groups as “recovered” and “unrecovered”, according to their response to the treatment. We found a statistically significant higher level of total cholesterol in the unrecovered group compared to the recovered one (p = 0.03). None of the other routine laboratory parameters have shown a statistically significant difference between the patients successfully treated and patients with poor outcomes. Total cholesterol concentrations may be a prognostic factor for recovery in ISSHL and should be assessed together with routine tests in patients with this condition. The other routine laboratory parameters seem to have no effect on the development and prognosis of this pathology.