Time-related association between fluid balance and mortality in sepsis patients: interaction between fluid balance and haemodynamics
Time-related association between fluid balance and mortality in sepsis patients: interaction between fluid balance and haemodynamics
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DOI：
10.1038/s41598-018-28781-4
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发表时间：
2018-07-10
影响因子：
4.6
通讯作者：
Zhang, Weimin
中科院分区：
文献类型：
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作者：
Shen, Yanfei;Ru, Weizhe;Zhang, Weimin
本研究旨在研究累积液体平衡（FB）与死亡率之间的时间相关性。数据来自重症监护医学信息市场（MIMIC）III。分析了8584例患者在重症监护室入院后第一个（FB-fir 24 hr）和第二个（FB-sec 24 hr）24小时的FB数据。与FB-fir 24 hr 0）的组合相比显著高。此外，多变量logistic分析显示，随着FB-sec 24 hr四分位数的增加，死亡率的OR显著逐步增加，除四分位数4外，FB-fir 24 hr四分位数无显著增加。在FB阴性的患者中，随着FB-sec 24 hr四分位数的增加，死亡率OR逐步降低，FB-fir 24 hr四分位数无显著差异。总之，在第二个而不是第一个24小时内FB阳性与败血症死亡率增加相关。实现更多的负FB仅在第二个24小时内与死亡率降低相关。
This study aimed to investigate the time-related association between cumulative fluid balance (FB) and mortality. Data were extracted from the Medical Information Mart for Intensive Care (MIMIC) III. FB data on 8584 patients at the first (FB-fir24hr) and second (FB-sec24hr) 24 hours after intensive care unit admission were analysed. Compared to the combination of FB-fir24hr 0) were significantly high. Furthermore, multivariable logistic analysis showed a significant stepwise increase ORs for mortality with increasing FB-sec24hr quartiles, with no significant increase in FB-fir24hr quartiles aside from quartile 4. In patients with negative FB, a stepwise decrease in mortality ORs with increasing FB-sec24hr quartiles was found with no significant difference in FB-fir24hr quartiles. In conclusion, the positive FB during the second but not the first 24 hours was associated with increased mortality in sepsis. Achieving more negative FB was associated with decreased mortality only in the second 24 hours.