Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress
Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress
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DOI：
10.1016/j.jaci.2006.01.036
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发表时间：
2006-05-01
影响因子：
14.2
通讯作者：
Miller, Gregory E.
中科院分区：
文献类型：
--
作者：
Chen, Edith;Hanson, Margaret D.;Miller, Gregory E.
背景资料：虽然社会环境变量如社会经济地位（SES）与儿童哮喘有关，但对这种关系背后的心理生物学机制知之甚少。目的：本研究的目的是探讨SES、心理应激和免疫过程与哮喘的关系。方法：37名9至18岁的儿童，医生诊断患有哮喘，39名健康儿童参加。家庭接受采访的慢性生活压力，威胁的看法，和SES。结果：在哮喘患儿中，SES水平降低与IL-5、IL-13水平升高和嗜酸性粒细胞计数升高相关（P <0.05），SES水平降低与IL-4、IL-5、IL-13水平升高和嗜酸性粒细胞计数升高相关（P <0.05），SES水平升高与IL-5、IL-13水平升高和嗜酸性粒细胞计数升高相关（P <0.05），SES水平升高与IL-5、IL-13水平升高和嗜酸性粒细胞计数升高相关（P <0.05）。
Background: Although social environment variables such as socioeconomic status (SES) have been linked to childhood asthma, little is known about the psychobiological mechanisms underlying this relationship.Objectives: The goal of this study was to investigate relationships among SES, psychological stress, and immune processes implicated in asthma.Methods: Thirty-seven children ages 9 to 18 years, physician-diagnosed with asthma, and 39 healthy children participated. Families were interviewed about chronic life stress, perceptions of threat, and SES. Blood samples were drawn from children to assess stimulated production of cytokines implicated in asthma (IL-4, IL-5, IL-13) and eosinophil counts.Results: In children with asthma, lower SES was associated with heightened production of IL-5 and IL-13 and higher eosinophil counts (P values