Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?
Increased primary autoimmune thyroid diseases and thyroid antibodies in sarcoidosis: evidence for an under-recognised extrathoracic involvement in sarcoidosis?
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DOI：
10.14310/horm.2002.1375
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发表时间：
2012-10-01
影响因子：
3.2
通讯作者：
Daniil, Zoe
中科院分区：
文献类型：
--
作者：
Malli, Foteini;Bargiota, Alexandra;Daniil, Zoe
目的和设计：结节病与甲状腺疾病有关。然而，到今天为止，还没有得出明确的结论。我们的目标是评估68例结节病患者和75名对照组甲状腺疾病的发生率以及甲状腺激素和甲状腺抗体水平。此外，我们还进行了超声检查和细针抽吸。结果：在希腊拉里萨大学医院进行的这项前瞻性病例对照研究中，29.4%的患者存在显性甲状腺疾病，16.1%的患者出现临床自身免疫性甲状腺疾病。结节病患者的血清自身免疫率明显较高。女性患者TSH受体抗体(Trabs)和抗甲状腺过氧化物酶抗体(TPOAbbs)阳性率显著高于性别匹配的对照组(40%vs0%，P
OBJECTIVE AND DESIGN: Sarcoidosis has been associated with thyroid diseases. However, until today no definite conclusions have been drawn. We aimed to assess the frequency of thyroid disorders and the levels of thyroid hormones and thyroid antibodies in 68 sarcoidosis patients and 75 controls. Additionally, we performed ultrasonography and fine-needle aspiration. RESULTS: In this prospective case control study conducted in the University Hospital of Larissa, Greece, overt thyroid disease was present in 29.4% of patients and 16.1% of patients presented clinical autoimmune thyroid disease. Sarcoidosis patients had a significantly higher frequency of serological autoimmunity. Female patients had significantly increased frequency of positive TSH receptor antibodies (TRAbs) and antithyroid peroxidase antibodies (TPOAbs) when compared to gender-matched controls (40% vs 0%, p