EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT
EFFECTS OF ANESTHETIC PROTOCOL ON NORMAL CANINE BRAIN UPTAKE OF 18F-FDG ASSESSED BY PET/CT
复制标题
DOI：
10.1111/j.1740-8261.2009.01636.x
复制
发表时间：
2010-03-01
影响因子：
1.7
通讯作者：
Eom, Kidong
中科院分区：
文献类型：
--
作者：
Lee, Min Su;Ko, Jeff;Eom, Kidong
本研究的目的是用正电子发射断层扫描/计算机断层扫描(PET/CT)技术评价四种麻醉方案对正常犬脑摄取2-脱氧-2-[18F]氟-d-葡萄糖(FDG)的影响。5只临床正常的Beagle犬以随机交叉设计的方法麻醉：(1)异丙酚/异氟醚，(2)美托咪定/戊巴比妥钠，(3)赛拉嗪/氯胺酮，(4)美地托咪定/替莱他明-唑拉西潘。获得额叶、顶叶、颞叶、枕叶、小脑、脑干和全脑的FDG标准摄取值(SUV)，并用Friedman检验比较麻醉方案内和麻醉方案之间的差异，P<；0.05。观察到与每种麻醉方案相关的大脑不同部分的SUV显著不同。在所有狗中，额叶和枕叶的SUV显著高于脑干。与异丙酚/异氟醚组相比，接受美托咪定/替莱他明-唑拉西潘治疗的狗的全脑SUV也明显更高。我们得出的结论是，每种麻醉方案都发挥了不同的脑部葡萄糖摄取模式。因此，当使用PET/CT比较大脑葡萄糖摄取时，应该考虑麻醉方案对狗大脑不同区域葡萄糖摄取的影响。
The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2-deoxy-2-[18F]fluoro-d-glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine-zolazepam in a randomized cross-over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P < 0.05. Significant differences in SUVs were observed in various part of the brain associated with each anesthetic protocol. The SUV for the frontal and occipital lobes was significantly higher than in the brainstem in all dogs. Dogs receiving medetomidine/tiletamine-zolazepam also had significantly higher whole brain SUVs than the propofol/isoflurane group. We concluded that each anesthetic protocol exerted a different regional brain glucose uptake pattern. As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.