Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids
Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids
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DOI：
10.1038/s41370-019-0114-9
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发表时间：
2020-01-01
影响因子：
4.5
通讯作者：
Wise, Lauren A.
中科院分区：
文献类型：
--
作者：
Bethea, Traci N.;Wesselink, Amelia K.;Wise, Lauren A.
我们进行了一项横断面分析，以确定七种酚类（双酚A、F和S; 2，4-二氯苯酚; 2，5-二氯苯酚;二苯甲酮-3;三氯生）、三氯卡班和四种对羟基苯甲酸酯（丁基、乙基、甲基和丙基）的尿液浓度的相关性。我们分析了766名参与环境，生活方式和纤维瘤研究的参与者的基线数据，这是一项前瞻性队列研究，涉及1693名居住在密歇根州底特律的23-34岁黑人女性（2010-2012）。我们通过电话采访、诊所访问和自我问卷调查收集了关于人口统计学、行为和人体测量因素的数据。对于每种生物标志物，我们使用线性回归模型来估计感兴趣的因素之间对数转换的肌酐校正浓度的平均差异。在>50%的参与者中检测到每种生物标志物。对羟基苯甲酸甲酯（116.8 μ g/g肌酐）、对羟基苯甲酸丙酯（16.8 μ g/g肌酐）和二苯甲酮-3（13.4 μ g/g肌酐）的肌酐校正浓度中位数最高。与生物标志物浓度最密切相关的变量包括尿液采集季节、教育程度和体重指数（BMI）。BMI与双酚A和S以及三氯卡班浓度呈正相关，与对羟基苯甲酸丁酯和甲酯浓度呈负相关。在这个黑人女性队列中，普遍暴露于酚类、对羟基苯甲酸酯和三氯卡班，有几个因素与生物标志物浓度相关。
We performed a cross-sectional analysis to identify correlates of urinary concentrations of seven phenols (bisphenols A, F, and S; 2,4-dichlorophenol; 2,5-dichlorophenol; benzophenone-3; triclosan), triclocarban, and four parabens (butyl, ethyl, methyl, and propyl). We analyzed baseline data from 766 participants in the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study of 1693 Black women aged 23-34 years residing in Detroit, Michigan (2010-2012). We collected data on demographic, behavioral, and anthropometric factors via telephone interviews, clinic visits, and self-administered questionnaires For each biomarker, we used linear regression models to estimate mean differences in log-transformed, creatinine-corrected concentrations across factors of interest. Each biomarker was detected in >50% of participants. Median creatinine-corrected concentrations were the highest for methyl paraben (116.8 mu g/g creatinine), propyl paraben (16.8 mu g/g creatinine), and benzophenone-3 (13.4 mu g/g creatinine). Variables most strongly associated with biomarker concentrations included season of urine collection, education, and body mass index (BMI). BMI was positively associated with bisphenol A and S and triclocarban concentrations and inversely associated with butyl and methyl paraben concentrations. In this cohort of Black women, exposure to phenols, parabens, and triclocarban was prevalent and several factors were associated with biomarker concentrations.