Translocations, master genes, and differences between the origins of acute and chronic leukemias
Translocations, master genes, and differences between the origins of acute and chronic leukemias
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易位、主基因以及急性和慢性白血病起源之间的差异
DOI：
10.1016/0092-8674(91)90057-6
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发表时间：
1991
期刊：
影响因子：
64.5
通讯作者：
T. Rabbitts
中科院分区：
文献类型：
--
作者：
T. Rabbitts
白血病起源于干细胞或骨髓和淋巴谱系，急性或慢性形式具有截然不同的临床模式。例如，慢性白血病通常起病隐匿，而急性白血病通常起病突然。另外，急性白血病（粒细胞除外）的发病高峰期为2～3岁儿童；慢性白血病在老年患者中的发病率往往更高。这些临床特征表明，急性和慢性白血病之间的肿瘤发展机制不同，由不同的体细胞获得性遗传变化介导。白血病的一个特征是存在被认为与肿瘤发展有关的特定染色体异常（在某些情况下通过实验证明，在其他情况下通过关联暗示）。对这些染色体畸变断点附近基因的分子研究以及对其基因产物功能的研究已经阐明了染色体易位在肿瘤发生和进展中的一般作用。更远-
Leukemias originate from stem cells or in the myeloid and lymphoid lineages, the acute or chronic forms having quite distinct clinical patterns. For example, chronic leukemia usually has an insidious onset, while acute leukemias usually manifest an abrupt onset. In addition, the acute leukemias (except myeloid) have aa peak of incidence in children around the age of two to three years; the chronic leukemias tend to have a greater incidence in older patients. These clinical features suggest different mechanisms in tumor development between acute and chronic leukemias mediated by different, somatically acquired genetic changes.A characteristic of leukemias is the presence of specific chromosome abnormalities considered to be involved in tumor development (proven experimentally in some cases and implicated by association in others). Molecular studies of genes adjacent to the breakpoints of these chromosome aberrations and studies on the function of their gene products have elucidated the general role of chromosome translocations in tumor initiation and progression. Further-
影响因子：
56.9
作者：
OETTINGER, MA;SCHATZ, DG;BALTIMORE, D
通讯作者：
BALTIMORE, D