Intermediate filaments as signaling platforms.
Intermediate filaments as signaling platforms.
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DOI：
10.1126/stke.3662006pe53
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发表时间：
2006-12-19
期刊：
影响因子：
--
通讯作者：
Eriksson, John E
中科院分区：
文献类型：
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作者：
Pallari, Hanna-Mari;Eriksson, John E
中间丝（IF）是细胞骨架结构，对于维持细胞和组织的结构和机械完整性至关重要。有趣的是，一个广泛的以前未知的非机械作用的IF细胞骨架正在出现：最近的研究已经联系到IF的整合信号有关的决定细胞的大小，细胞迁移和细胞存活的调节，以及缓冲的影响，应力激活激酶。这种高度丰富的蛋白质的不同家族成员的特征性结构特征和表达模式使它们非常适合充当细胞和组织特异性的信号传导修饰剂和组织者。
Intermediate filaments (IFs) are cytoskeletal structures that are crucial for maintaining the structural and mechanical integrity of cells and tissues. Intriguingly, a wide range of previously unknown nonmechanical roles for the IF cytoskeleton are emerging: Recent studies have linked IFs to the integration of signals related to the determination of cell size, the regulation of cell migration and cell survival, and the buffering of the effects of stress-activated kinases. The characteristic structural features and expression patterns of the different members of this diverse family of highly abundant proteins make them well suited to act as cell- and tissue-specific modifiers and organizers of signaling.