Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index
Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index
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DOI：
10.3109/00365511003650165
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发表时间：
2010-04-01
影响因子：
2.1
通讯作者：
Kono, Suminori
中科院分区：
文献类型：
--
作者：
Ikeda, Mizuko;Maki, Takako;Kono, Suminori
目标。以前的研究表明，咖啡消费量与血清肝酶水平呈负相关，如丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)和伽马-谷氨酰转移酶(GGT)，但很少有人研究女性的这种关系以及酒精使用和肥胖的影响。我们研究了自由生活的日本男性和女性饮用咖啡和绿茶与血清肝酶活性的关系，重点是性别差异以及酒精和肥胖的影响。材料和方法。这些数据来自九州大学福冈队列研究的基线调查，包括12020名年龄在49岁至76岁之间的日本男性和女性，他们没有慢性肝病。结果。在男性中，喝咖啡与ALT升高之间存在负相关，而在女性中，两者之间的关联较弱。在按转氨酶类别分层的分析中，在整个范围内以及转氨酶在参考范围内的男性和女性中，咖啡摄入量与血清肝酶活性均呈负相关(男性ALT/AST<；40IU/L，女性ALT/AST<；30IU/L)。咖啡与肝酶的反向关联在高饮酒量和低体重指数的人中更加明显。结论。喝咖啡可能会对酒精引起的肝酶升高起到保护作用。
Objective. Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of coffee and green tea consumption with serum activities of liver enzymes in free-living Japanese men and women, focusing on sex difference and effect modifications of alcohol and obesity. Material and methods. The data were derived from the baseline survey of the Kyushu University Fukuoka Cohort Study, and included 12,020 Japanese men and women aged 49-76 years who were free of chronic liver diseases. Results. There was an inverse association between coffee consumption and elevated ALT in men, and the association between the two was weaker in women. In the analyses stratified by aminotransferases category, inverse associations of coffee consumption with serum activities of liver enzymes were observed in both men and women within the whole range and among those with aminotransferases within the reference range (ALT/AST < 40 IU/L for men and ALT/AST < 30 IU/L for women). Inverse associations of coffee with liver enzymes were more evident in those with high alcohol consumption and in those with low body mass index. Conclusions. Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.