The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus
The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus
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DOI：
10.1111/dom.12122
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发表时间：
2013-11-01
影响因子：
5.8
通讯作者：
Hillis, G. S.
中科院分区：
文献类型：
--
作者：
Blomster, J. I.;Chow, C. K.;Hillis, G. S.
目的：关于2型糖尿病患者体力活动与血管并发症，特别是微血管疾病之间的关系，证据有限。方法从ADVANCE（糖尿病和血管疾病的作用：Preterax和Diamicron改良释放控制评价）试验的11140例患者中，通过调整潜在混杂因素的多变量回归模型检查身体活动的影响，分为无，轻度，中度或剧烈，以及一周内的运动次数。研究终点为主要心血管事件、微血管并发症和全因死亡率。结果：46%的参与者报告说，他们在前一周至少进行了一次每天150分钟的中度到剧烈的体育锻炼。在中位5年的随访期间，1031例患者死亡，1147例发生主要心血管事件，1136例发生微血管事件。与不进行体育锻炼或轻度体育锻炼的患者相比，中度至剧烈体育锻炼的患者心血管事件的风险降低(HR: 0.78, 95% CI: 0.69-0.88, p
AimsThere is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes.MethodsFrom the 11140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end-points were major cardiovascular events, microvascular complications and all-cause mortality.ResultsForty-six percent of participants reported undertaking moderate to vigorous physical activity for >15min at least once in the previous week. During a median of 5years of follow-up, 1031 patients died, 1147 experienced a major cardiovascular event and 1136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events (HR: 0.78, 95% CI: 0.69-0.88, p