Comparison of bladder blood flow in patients with and without interstitial cystitis
Comparison of bladder blood flow in patients with and without interstitial cystitis
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DOI：
10.1016/s0022-5347(05)68552-7
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发表时间：
1999-08-01
影响因子：
6.6
通讯作者：
Ruggieri, MR
中科院分区：
文献类型：
--
作者：
Pontari, MA;Hanno, PM;Ruggieri, MR
目的：我们比较了间质性膀胱炎患者和非间质性膀胱炎患者充盈和排空过程中的血流，以及间质性膀胱炎患者的血流与症状的相关性。材料和方法：采用双通道内窥镜激光多普勒血流探头测量膀胱血流灌注，在80 cm范围内，从膀胱粘膜的三角区和后壁开始测量浅表和深层的血管床，测量清醒容量。水肿胀和膀胱引流后。术前行美国泌尿外科协会间质症状评分。结果：间质性膀胱炎患者各区域膀胱灌注量随充盈程度降低，非间质性膀胱炎患者膀胱灌注量增加。两组对排空膀胱的反应没有显著差异，因为两组的灌注量都有增加的趋势。结论：间质性膀胱炎患者的膀胱灌注量随着充盈程度的增加而减少，而非间质性膀胱炎患者的膀胱灌注量增加。间质性膀胱炎膀胱不能通过充盈增加膀胱血流量，这可能是膀胱粘膜其他病理过程的反映。血流和症状之间缺乏相关性表明，仅有膀胱缺血不能解释间质性膀胱炎的症状。
Purpose: We compared bladder blood flow during filling and emptying in patients with and without interstitial cystitis, and correlated blood flow with symptoms in those with interstitial. cystitis.Materials and Methods: Bladder perfusion was measured using a dual channel endoscopic laser Doppler flow probe, Measurements were obtained in superficial and deeper vascular beds from the bladder mucosa at the trigone and back wall at baseline, at the volume of awake capacity, during 80 cm. water hydrodistention and after bladder drainage. American Urological Association symptom score was obtained preoperatively in interstitial. cystitis patients.Results: In all areas bladder perfusion decreased with filling in interstitial cystitis patients and increased in those without interstitial cystitis. There were no significant differences in response to emptying the bladder, as perfusion tended to increase in both groups. There was no correlation between bladder perfusion at baseline, or in response to filling or emptying with overall symptom score.Conclusions: Bladder perfusion decreases with bladder filling in patients with but increases in those without interstitial cystitis. The inability of the interstitial cystitis bladder to increase bladder blood flow with filling may be a reflection of other pathological processes in the bladder mucosa. The lack of correlation between blood flow and symptoms suggests that bladder ischemia alone cannot account for the symptoms in interstitial cystitis.