High expression of PALB2 predicts poor prognosis in patients with advanced breast cancer.
High expression of PALB2 predicts poor prognosis in patients with advanced breast cancer.
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PALB2高表达预示晚期乳腺癌患者预后不良
DOI：
10.1002/2211-5463.12356
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发表时间：
2018-01
期刊：
影响因子：
2.6
通讯作者：
Ba Q
中科院分区：
文献类型：
--
作者：
Li J;Li M;Chen P;Ba Q
PALB 2突变与乳腺癌风险增加相关;然而，PALB 2突变在散发性乳腺癌病例中很少见，并且对PALB 2在乳腺癌中的表达知之甚少。在这里，我们用117名女性乳腺癌患者的组织微阵列标本评估了PALB 2的预后作用，并确定了细胞模型中潜在的潜在机制。免疫组化结果显示，PALB 2在乳腺癌组织中的表达明显高于癌旁正常乳腺导管上皮（P < 0.001）。PALB 2评分与组织学分级呈正相关，Her-2阴性患者的PALB 2表达高于阳性患者（P < 0.05）。有趣的是，在III期或邻近淋巴结转移（N1、N2或N3）的患者中，PALB 2的高表达与总生存率显著相关（P < 0.01）。体外研究发现PALB 2可能通过抑制E-钙粘蛋白和激活NF-κB促进MDA-MB-231细胞的迁移和侵袭。总之，这些结果表明，PALB 2表达水平可能作为一种新的乳腺癌患者的预后因素。
PALB2 mutation is associated with increased breast cancer risk; however, PALB2 mutation is rare in sporadic breast cancer cases and little is known about PALB2 expression in breast cancer. Here, we evaluated the prognostic effects of PALB2 with tissue microarray specimens of 117 female breast cancer patients, and determined the potential underlying mechanisms in cell models. In immunohistochemical analysis, we found increased expression of PALB2 in breast cancer tissues compared with the adjacent normal ductal epithelium (P < 0.001). Higher PALB2 scores were positively associated with histological grade and higher PALB2 expression was found in patients that were Her‐2 negative compared with those that were positive (P < 0.05). Interestingly, higher expression of PALB2 was significantly associated with poorer overall survival (P < 0.01) in patients with stage III or nearby lymph node metastasis (N1, N2 or N3). In vitro studies found that PALB2 may promote the migration and invasion of MDA‐MB‐231 cells through E‐cadherin suppression and NF‐κB activation. In conclusion, these results suggest that PALB2 expression levels may serve as a novel prognostic factor for breast cancer patients.
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