Natural selection shaped the rise and fall of passenger pigeon genomic diversity
Natural selection shaped the rise and fall of passenger pigeon genomic diversity
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DOI：
10.1126/science.aao0960
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发表时间：
2017-11-17
期刊：
影响因子：
56.9
通讯作者：
Shapiro, Beth
中科院分区：
文献类型：
--
作者：
Murray, Gemma G. R.;Soares, Andre E. R.;Shapiro, Beth
已经灭绝的旅鸽曾经是北美，甚至可能是世界上数量最多的鸟类。虽然理论预测大的种群会有更多的遗传多样性，但旅鸽的遗传多样性却出奇的低。为了调查这种脱节，我们分析了旅鸽的41个线粒体基因组和4个核基因组以及带尾鸽的2个基因组，它们是旅鸽现存的最近亲属。旅鸽庞大的种群规模似乎允许更快的适应性进化和去除有害突变，导致其中性遗传多样性的巨大损失。这些结果证明了选择对脊椎动物基因组的影响，并与表明种群不稳定导致该物种令人惊讶的快速灭绝的结果相矛盾。
The extinct passenger pigeon was once the most abundant bird in North America, and possibly the world. Although theory predicts that large populations will be more genetically diverse, passenger pigeon genetic diversity was surprisingly low. To investigate this disconnect, we analyzed 41 mitochondrial and 4 nuclear genomes from passenger pigeons and 2 genomes from band-tailed pigeons, which are passenger pigeons' closest living relatives. Passenger pigeons' large population size appears to have allowed for faster adaptive evolution and removal of harmful mutations, driving a huge loss in their neutral genetic diversity. These results demonstrate the effect that selection can have on a vertebrate genome and contradict results that suggested that population instability contributed to this species's surprisingly rapid extinction.