Matrix stiffness and its influence on pancreatic diseases.
Matrix stiffness and its influence on pancreatic diseases.
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DOI：
10.1016/j.bbcan.2021.188583
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发表时间：
2021-06
期刊：
影响因子：
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通讯作者：
Weifan Zhang;Simei Zhang;Wunai Zhang;Yangyang Yue;Weikun Qian;Zheng Wang
中科院分区：
文献类型：
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作者：
Weifan Zhang;Simei Zhang;Wunai Zhang;Yangyang Yue;Weikun Qian;Zheng Wang
细胞外基质（ECM）的基质刚度，即对细胞的缓慢弹性力，已逐渐成为研究。较高的硬度可引起细胞生物学行为的改变和内部信号通路的激活。ECM的不平衡刚度与许多疾病相关，包括胰腺疾病。在这篇综述中，我们讨论了ECM的组成部分和不平衡ECM变化引起的刚度增加。接下来，我们将详细描述基质硬度如何传递机械信号以及细胞内发生了哪些信号通路的改变。最后，我们从基质硬度的角度讨论了ECM对胰腺疾病行为的影响。
The matrix stiffness of the extracellular matrix(ECM), which is the slow elastic force on cells, has gradually become investigated. And a higher stiffness could induce changes in cell biological behaviors and activation of internal signaling pathways. Imbalanced stiffness of ECM is associated with a number of diseases, including pancreatic disease. In this review, we discuss the components of the ECM and the increased stiffness caused by unbalanced ECM changes. Next, we describe how matrix stiffness transmits mechanical signals and what signaling pathways are altered within the cell in detail. Finally, we discuss the effect of ECM on the behavior of pancreatic diseases from the perspective of matrix stiffness.