Regulation of poly(ADP-ribose) polymerase mRNA levels during compensatory and mitogen-induced growth of rat liver.
Regulation of poly(ADP-ribose) polymerase mRNA levels during compensatory and mitogen-induced growth of rat liver.
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DOI：
10.1016/0003-9861(90)90486-i
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发表时间：
1990-06
影响因子：
3.9
通讯作者：
M. Menegazzi;A. D. de Prati;G. Ledda-Columbano;A. Columbano;K. Uchida;M. Miwa;H. Suzuki
中科院分区：
文献类型：
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作者：
M. Menegazzi;A. D. de Prati;G. Ledda-Columbano;A. Columbano;K. Uchida;M. Miwa;H. Suzuki
聚（ADP-核糖）聚合酶的mRNA水平进行了研究，在肝再生后的部分肝切除术，并在增生诱导的有丝分裂原硝酸铅。一个显着增加的聚（ADP-核糖）聚合酶mRNA的水平被发现8小时后部分肝切除术时，没有检测到的DNA合成的增加可以观察到的聚（ADP-核糖）聚合酶转录水平增加了6倍，在1-2天内。硝酸铅处理后24小时，聚（ADP-核糖）聚合酶mRNA水平也出现类似的增加。在（a）部分肝切除术和（B）硝酸铅治疗后2天，观察到聚（ADP-核糖）聚合酶活性增加两倍。从这些结果中的一个重要作用的聚（ADP-核糖）聚合酶在细胞增殖中可以建议。
Poly(ADP-ribose) polymerase mRNA levels were studied in hepatic regeneration following partial hepatectomy, and in hyperplasia induced by the mitogen lead nitrate. A significant increase in the level of poly(ADP-ribose) polymerase mRNA was found 8 h after partial hepatectomy when no detectable increase of DNA synthesis could be observed; the level of poly(ADP-ribose) polymerase transcripts increased up to six-fold within 1–2 days. A similar increase of the level of poly(ADP-ribose) polymerase mRNA was found 24 h after treatment with lead nitrate. A twofold increase in poly(ADP-ribose) polymerase activity was observed 2 days after (a) partial hepatectomy and (b) lead nitrate treatment. From these results an important role of poly(ADP-ribose) polymerase in cell proliferation could be suggested.