Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes.
Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes.
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发表时间：
1989-07
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影响因子：
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通讯作者：
Paul K. Pattengale;Timothy A. Stewart;Aya Leder;E. Sinn;William J. Muller;I. Tepler;Emmett V. Schmidt;Philip Leder
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作者：
Paul K. Pattengale;Timothy A. Stewart;Aya Leder;E. Sinn;William J. Muller;I. Tepler;Emmett V. Schmidt;Philip Leder
本文对携带和表达活化细胞癌基因的转基因小鼠的自发性肿瘤进行了综述。简要回顾了转基因小鼠作为体内疾病模型的历史发展，随后简要描述了此类系统中的实际技术。此外，还强调了将激活的细胞癌基因靶向转基因小鼠特定组织的概念。详细考虑了转基因小鼠中(Vmyc、ras和neu(erb-B2)癌基因被激活的累积经验，特别关注观察到的病理以及疾病发生的动力学。结论是转基因小鼠为感兴趣的研究者(S)提供了一个很好的体内肿瘤发生的前瞻性模型。
This present review focuses on spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes. The historical development of transgenic mice as in vivo disease models is briefly traced, followed by a brief description of the actual technology in such systems. Additional emphasis is placed on the concept of targeting activated cellular oncogenes to specific tissues in transgenic mice. Cumulative experience with activated (Vmyc, ras, and neu (erb-B2] oncogenes in transgenic mice is considered in detail, with particular attention paid to the observed pathology, as well as to the kinetics of disease occurrence. It is concluded that transgenic mice offer the interested investigator(s) an excellent prospective, in vivo model of oncogenesis.