P300 AMPLITUDE IN NON-BIPOLAR, MELANCHOLIC DEPRESSION
P300 AMPLITUDE IN NON-BIPOLAR, MELANCHOLIC DEPRESSION
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DOI：
10.1016/0165-0327(93)90077-w
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发表时间：
1993-05-01
影响因子：
6.6
通讯作者：
UMAPATHY, C
中科院分区：
文献类型：
--
作者：
GANGADHAR, BN;ANCY, J;UMAPATHY, C
对17例无药物治疗的抑郁症患者和22例正常对照，采用听觉“古怪”范式记录P300事件相关电位(ERP)。13例患者在ECT恢复后进行重复的事件相关电位记录。治疗前P300潜伏期在患者和对照组之间没有差异，抑郁症患者在康复后也没有变化。抑郁症患者治疗前P300波幅小于对照组(P<；0.02)，且与病情严重程度呈负相关(P<；0.05)。恢复期患者P300波幅显著增加(P<；0.05)，恢复正常。P300可能是抑郁症的状态标记物。
P300 event related potential (ERP) was recorded using the auditory 'oddball' paradigm in 17 melancholic, drug-free depressive patients and 22 normal controls. Repeat ERP recordings were obtained from 13 patients after recovery with ECT. Pretreatment P300 latencies were not different between patients and controls, nor did they change in the depressives following recovery. Pretreatment P300 amplitudes in depressives were smaller (P < 0.02) than in controls and negatively correlated with severity (P < 0.05). P300 amplitudes significantly increased in patients following recovery (P < 0.05) and normalized. P300 may be a state marker for melancholic depression.