Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
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DOI：
10.1128/iai.00142-06
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发表时间：
2006-07-01
影响因子：
3.1
通讯作者：
Morschhaeuser, Joachim
中科院分区：
文献类型：
--
作者：
Bader, Teresa;Schroeppel, Klaus;Morschhaeuser, Joachim
通过在一个新的可回收显性选择标记的帮助下产生白色念珠菌野生型菌株SC 5314的钙调神经磷酸酶突变体，我们证实了钙调神经磷酸酶介导对各种应激条件的耐受性，但不是C.白念珠菌切换到丝状生长响应菌丝诱导的环境信号。而钙调神经磷酸酶是C.在播散性念珠菌病的小鼠模型中，CMPI的缺失没有显著影响阴道或肺部感染期间的毒力，表明成功感染对钙调神经磷酸酶的需求取决于宿主生态位。
By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMPI did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.