Effect of age on contractility of guinea pig ureter.
Effect of age on contractility of guinea pig ureter.
复制标题
年龄对豚鼠输尿管收缩力的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Weiss
中科院分区：
文献类型：
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作者：
K. W. Hong;P. Biancani;R. Weiss
在体外研究了3周、3个月和3岁动物的豚鼠输尿管纵向力-长度关系。远段3周的孩子经历了一个更大的百分比增加的长度在响应施加的休息力比那些从老年组。近端节段的静息力-长度关系不受年龄的影响。在所有年龄和所有长度下，远端节段的主动力较高。最大作用力随年龄增长而增加。3周龄和3月龄之间的力量增加似乎是由于收缩力的增加，因为主动应力有相关的增加; 3月龄和3岁之间的增加与肌肉横截面积增加有关，但主动应力没有变化。这一发现表明，在此时间间隔内，收缩力没有发生变化。
Longitudinal force-length relationships of guinea pig ureter were studied in vitro in animals 3 weeks, 3 months, and 3 years of age. Distal segments of 3-week-olds underwent a greater per cent increase in length in response to an applied resting force than those from older age groups. Resting force-length relations of proximal segments were unaffected by age. Active force was higher in distal segments at all ages and at all lengths. Maximum active force increased with age. The increase in force developed between 3 weeks and 3 months of age seemed to be attributable to an increase in contractility since there was an associated increase in active stress; the increase developed between the 3-month- and 3-year-olds was associated with increased muscle cross-sectional area but with no change in active stress. This finding suggests that no change in contractility occurred during this time interval.