Late intrauterine Cytomegalovirus infection: Clinical and neuroimaging findings
Late intrauterine Cytomegalovirus infection: Clinical and neuroimaging findings
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DOI：
10.1016/s0887-8994(96)00170-1
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发表时间：
1996-10-01
影响因子：
3.8
通讯作者：
Boltshauser, EJ
中科院分区：
文献类型：
--
作者：
Steinlin, MI;Nadal, D;Boltshauser, EJ
妊娠早期胎儿巨细胞病毒（CMV）感染通常会导致严重的神经功能障碍和感音神经性听力损失，并伴有典型的神经放射学表现，如钙化、偏头痛、髓鞘形成障碍和小脑发育不全。妊娠晚期获得性感染的症状不太明显，如小头畸形、听力障碍和轻微的神经障碍。我们报告了7名儿童，他们表现出类似的临床综合征：小头畸形，感觉神经性听力障碍，行为问题伴多动，其中5名对疼痛的恐惧减少，3名共济失调，另外3名肌张力减退伴笨拙，所有这些都表现出轻度至重度的发育问题，6名患者中有4名头颅CT显示钙化。所有7名儿童的MRI均显示斑片状至融合的非进行性髓鞘形成障碍。只有2名儿童有先天性CMV感染的急性新生儿体征，我们认为这些儿童在妊娠晚期获得CMV感染，导致小头畸形，听力损失，神经和发育问题，具有典型的神经放射学体征。(C)Elsevier Science Inc.出版。All rights reserved.
Fetal Cytomegalovirus (CMV) infection in early pregnancy usually results in severe neurological handicap and sensorineural hearing loss with typical neuroradiological findings of calcification, migrational anomalies, disturbed myelination, and cerebellar hypoplasia. Infections acquired in late pregnancy have less prominent signs, such as microcephaly, hearing deficits, and minor neurological handicap. We report 7 children who presented with a similar clinical complex of signs: microcephaly, sensorineural hearing impairment, behavior problems with hyperactivity, reduced apprehension for pain in 5 of the 7, ataxia in 3, and hypotonia with clumsiness in 3 others, All manifested mild to severe developmental problems, Cranial CT revealed calcification in 4 of 6 patients. MRI in all 7 children showed patchy to confluent nonprogressive dysmyelination. Only 2 children had acute neonatal signs of congenital CMV infection, We assume that these children acquired CMV infection in the third trimester of gestation, leading to microcephaly, hearing loss, and neurological and developmental problems with typical neuroradiological signs. (C) 1996 by Elsevier Science Inc. All rights reserved.